Abstract 3759: Abdominal Aortic Wall-Thickness by Magnetic Resonance Imaging and Subclinical Coronary Atherosclerosis in a Multi-ethnic Population-Based Study
# Objective: To examine the association of coronary artery calcium (CAC) and aortic wall-thickness (AWT), indicators of subclinical atherosclerosis, adjusting for the prevalence of cardiovascular risk factors.
Methods: Electron Beam Computed Tomography measurements of coronary artery calcium (CAC) and MRI measurements of aortic wall-thickness (AWT) were performed in 2198 and 1965 subjects, respectively. Aortic wall thickness (AWT) was defined as the ratio of wall area to mean aortic circumference. Weighted analyses, logistic regression and nonparametric analyses were performed to evaluate the association of CAC, AWT and the prevalence of cardiovascular risk factors.
Results: The prevalence of detectable CAC (CAC score ≥10) was 20.4% in this sample. AWT was significantly higher in participants with detectable CAC (P < .001). The median AWT in participants with detectable CAC was 1.88 mm (interquartile range [IQR], 1.69 –2.12 mm), whereas in those with no CAC was 1.64 mm (IQR, 1.47–1.79). In multivariate logistic regression analyses, AWT was identified as positively associated with the prevalence of coronary artery calcification after adjusting for age, sex, ethnicity and history of diabetes, hypertension, hyperlipidemia and smoking (odds ratio, 3.2; 95% confidence interval, 2.1– 4.9; P < .001).
Conclusions: Aortic wall thickness is an independent marker for the prevalence of subclinical coronary atherosclerosis. Further studies examining the potential value of aortic wall thickness as an indicator of subclinical atherosclerosis to guide the response of preventive interventions are warranted.