Abstract 3752: NMR Lipoprotein Subfractions And Subclinical Atherosclerosis - The GOCADAN Study
Background While the role of plasma lipids in the definition of cardiovascular risk is very well established, the relationship between individual lipoprotein subfractions and the atherosclerotic process has not been clarified.
Aim The aim of this study was to evaluate the relationship between different lipoprotein subfractions and early subclinical atherosclerosis in Alaska natives participating in the GOCADAN Study.
Methods In a population based sample of 760Alaska Eskimos (>=35 yrs, 343 men, 417 women) without diabetes lipoprotein particle distribution (large, intermediate and small VLDL,LDL and HDL) and size were evaluated by Nuclear Magnetic Resonance (NMR) and related to carotid intimal-medial thickness (IMT) and extent of atherosclerosis (score of 0 – 8 segments containing plaque), evaluated by standardized 2-dimensional B-mode ultrasonography.
Results Mean age, BMI, LDL-C, HDL-C and TG averaged 51yrs, 27.6 kg/m2, 124 mg/dL, 68mg/dL, and 128 mg/dL, respectively. IMT (mean 0.66, range 0.34 –1.10mm) tertiles were significantly associated with an increase in large VLDL particles (p<0.02) and in total LDL (p<0.04). Plaque score was directly correlated with large VLDL (p= 0.04), and inversely with total HDL (p=0.07). All these associations were independent of age, gender, BMI , blood pressure, and smoking.
Conclusions These finding suggest that an increase in large VLDL is the most consistent abnormality in lipoprotein subfraction distribution associated with both carotid IMT and plaque score, which have been shown to be strong predictors of subsequent clinical events. Thus abnormalities in VLDL metabolism may play a major role in the development of atherosclerosis.