Abstract 3689: Circulating Levels of Resistin in Relation to Metabolic Markers and Risk of Developing Type 2 Diabetes in Postmenopausal Women
BACKGROUND: Resistin, as an adipocyte-derived hormone, promotes obesity-associated insulin resistance in rodents. However, few human population data are available evaluating the relations of circulating resistin levels with metabolic factors and future risk of type 2 diabetes.
METHODS: We conducted a prospective, nested case-control study among postmenopausal women not using hormone therapy and without a history of cardiovascular disease, diabetes, or cancer in the Women’s Health Study. During 10 years of follow-up, 359 incident diabetes cases were matched with 359 controls by age, ethnicity, and fasting status at time of blood draw.
RESULTS: At baseline, resistin levels were positively and modestly correlated with BMI (r=0.22, P<0.0001). Resistin was also positively associated with systolic BP (r=0.11, P=0.004), diastolic BP (r=0.12, P<0.002), and triglyceride levels (r=0.17, P< 0.0001), and inversely associated with HDL-cholesterol levels (r=−0.18, P < 0.0001). The correlations with triglyceride and HDL-cholesterol remained significant, even after adjusting for BMI. Median baseline levels of resistin were significantly higher among diabetes cases than among controls (11.7 vs. 10.4 ng/mL; P < 0.0001). After adjustment for matching factors, total calorie intake, exercise, alcohol intake, smoking, and family history of diabetes, levels of resistin were significantly associated with risk of developing type 2 diabetes; the relative risk (RR) in highest versus lowest quartile was 2.12 (95% CI: 1.27–3.55, P for linear trend=0.003). However, additional adjustment for BMI markedly attenuated the association (RR=1.58, 95% CI: 0.87–2.85; P for linear trend=0.18).
CONCLUSIONS: Circulating resistin levels were significantly correlated with triglyceride and HDL-cholesterol levels independent of BMI. Higher levels of resistin predicted an elevated future risk of type 2 diabetes, but these associations were attenuated after adjustment for BMI.