Abstract 3670: Relationship Between Blood Pressure and Chronic Kidney Disease in the Japanese Population without Hypertension
INTRODUCTION: Whether “the lower the better” relationship between blood pressure and chronic kidney disease (CKD) holds true in individuals without hypertension remains unknown. This study was performed to assess the relationship between blood pressure and CKD in a Japanese population without hypertension.
METHODS: Among 13007 Japanese participants of a general health screening, 9596 (5691 men and 3905 women) were found to have either normal blood pressure or prehypertension, and were enrolled in the present study. We categorized individuals’ blood pressure into six classes: BP-C1, <90/<65mmHg; BP-C2, 90 –100/65–70mmHg; BP-C3, 100 –110/70 –75mmHg; BP-C4, 110 –120/75– 80mmHg; BP-C5, 120 –130/80 – 85mmHg; and BP-C6, 130 –140/85–90mmHg. Albuminuria was defined as a urinary albumin excretion ratio of ≥30mg/g. Low estimated glomerular filtration rate (eGFR) was defined as an eGFR of <60ml/min./1.73m2.
RESULTS: Multivariate logistic regression analysis adjusted for age, body mass index, serum lipid profiles, fasting plasma glucose and smoking status was performed and the results are shown in the Table⇓. In men, when BP-C3, the category with the lowest prevalence of albuminuria, was used as a reference, a significant graded increase in the risk for albuminuria was found in BP-C4, BP-C5 and BP-C6. In women, when BP-C1 was used as a reference, the increase in the risk for albuminuria was significant in both BP-C4 and BP-C6, and borderline significant in BP-C5. The risk for low eGFR did not significantly differ in non-hypertensive individuals of either gender.
CONCLUSIONS: The risk for albuminuria was significantly greater when blood pressure exceeded 110/75mmHg in both genders.