Abstract 3663: Sugar-sweetened Beverage Consumption And Risk Of Coronary Heart Disease In Women
We assessed the association between sugar-sweetened beverage (SSB) consumption and risk of coronary heart disease (CHD) in the ongoing Nurses’ Health Study cohort. Women aged 34–59 in 1980, without a history of cardiovascular disease and diabetes were followed for up to 22 years. Carbonated and non-carbonated sweetened beverage intakes were assessed 5 times during follow-up with a validated food frequency questionnaire. Cumulative averages of intake was calculated and Consumption frequency in servings were categorized into <1/month, 2–4/month, 2–6/week, 1 to < 2/d, and 2+/d. Lifestyle information was assessed every 2 years with a questionnaire. Relative risks of CHD were calculated with Cox proportional hazard models controlling for age, smoking, physical activity, menopausal status and post-menopausal hormone use, aspirin use, family history, history of hypertension and hypercholesterolemia, and intakes of alcohol, fiber whole grains , and total fat. We confirmed 2750 incident CHD, including 1867 non-fatal and 883 fatal cases. After adjusting for potential confounders, we observed a RR of 1.18 (95% CI=1.01–1.38) for total SSB comparing 2+/d to <1/month and, and a RR of 1.26 (95% CI 1.04–1.53) for regular colas for the same comparison. CHD risk was increased by 11% (p=0.0006) for every 2 servings per day increase of total SSB and by 17% (p=0.0008) for every 2 servings of regular colas. After additional adjustment for BMI and energy intake, the RRs were slightly attenuated but remained significant. There was no association between diet colas and risk of CHD. In conclusion, data from this large cohort of women suggest a positive association between regular consumption of SSB and CHD risk.