Abstract 3639: Diabetes Mellitus as a Predictor of Decreased Regional Myocardial Function in an Adult Population without Clinical Cardiovascular Disease: The Tagged MRI Follow-up Study of the Multi-Ethnic Study of Atherosclerosis (MESA)
Background: Diabetes is a known risk factor for heart failure (HF) morbidity and mortality, but no longitudinal studies have been reported evaluating whether diabetes is related to changes over time in regional left ventricular (LV) myocardial function.
Objective: To assess the relationship between diabetes and temporal change in regional LV systolic function, as assessed by tagged cardiac MRI studies.
Methods: Regional systolic circumferential strain (Ecc) from consecutive studies was analyzed by HARP at 2 separate points in time (average= 3.7 years) in 181 asymptomatic participants in MESA. Multiple linear regression analysis was used to analyze the difference in the temporal change strain ([Ecc2-Ecc1]/time in years) in those with and without diabetes at baseline. Model 1 included baseline Ecc and diabetes, Model 2 further adjusted for age and gender. Model 3 additionally adjusted for hypertension.
Results: Among the 181 participants (103 female), average age was 61.5 years and 19 had diabetes. Average changes were +3.17 ± 4.4 and -0.13 ± 0.25 (%change/year, mean ± se) in those with and without diabetes. As shown in the figure⇓, we found a significant reduction of regional systolic function (Ecc) in those with diabetes (p<0.05), compared to without diabetes in all regions in all three models, except for the septal wall in Model 3.
Conclusion We found a significant reduction in regional systolic function over a mean of 3.7 years among asymptomatic subjects with diabetes compared to those without diabetes in this longitudinal MRI tagging study. These results may have therapeutic implications for the prevention of heart failure among asymptomatic individuals with diabetes mellitus.