Abstract 3548: The Effect of Aerobic Training on C-Reactive Protein: Results of the INFLAME Study
Numerous cross-sectional studies show an inverse relation between regular exercise and C-reactive protein (CRP). However, data from current intervention trials are conflicting. To our knowledge there exist no properly powered studies specifically designed to examine the role of exercise in reducing CRP in individuals with elevated CRP. The goal of Inflammation and Exercise (INFLAME) trial was to determine the effect of aerobic exercise training on elevated (≥ 2.0 mg/L) CRP in initially sedentary women and men (18 to 75 years old). We randomly assigned 162 individuals equally to a no exercise control group or to an exercise group. Exercising individuals participated in 3–4 supervised training sessions each week for 4 months at total energy expenditure of 16 kcal/kg/week. Drop-out rate was low (<15%) and exercise adherence was high (>95%). The study group was 72% female and 35% ethnic minorities with a mean (SD) age of 50.6 (10.8) y and a mean BMI of 31.5 (4.1) kg/m2. Mean baseline CRP was 4.3 (2.5) mg/L and mean absolute VO2max was 1.7 (0.6) L/min. As shown in Panel A, individuals randomized to aerobic exercise did not have a significant improvement in CRP compared with control (p =0.47). However, weight loss in the exercise group was only 0.3 Kg compared with the predicted loss of 4 to 5 kg based on exercise energy expenditure. Interestingly, those in the exercise group who lost weight did have an improvement in CRP (Panel B, p = 0.007). In conclusion exercise is associated with a reduction in CRP only in the presence of weight loss.