Abstract 3540: Brisk walking increases high-density lipoproteon cholesterol level coupling with augmented fish oil intake: Sapporo Lifestyle Study
Background: High-density lipoprotein cholesterol (HDL-C) shows cardioprotective function. Japanese have relatively high HDL-C levels and more intake of fish oil, which may explain the low incidence of coronary artery disease in Japan among industrialized countries. We estimated whether therapeutic lifestyle change (TLC) for Japanese induces more increased HDL-C level.
Methods: Sapporo lifestyle study is a community-based, prospective, randomized controlled study to improve coronary risk profile by TLC consisting of exercise and dietary modification for 12 months. Three hundred nineteen residents aged 40 to 69 years without symptom were recruited with informed consent. After 3 persons were excluded by inclusion criteria, 316 eligible residents (male 111, female 205) were allocated into 3 groups such as 105 control (A), 106 exercise intervention (B), and 105 exercise with dietary intervention group. Brisk walking (near 3 METs) for 150 minutes a week was introduced for B and C groups, and a nutritional intervention consisting of appropriate energy intake for ideal body weight, increased n-3 polyunsaturated fatty acid (PUFA) up to 2.9gram a day and additional 2.0 gram increase of fiber intake a day, was instructed for C group in training sessions. All participants were estimated body composition, lipid profile, physical fitness, and nutritional status (by diet history questionnaire made in Japan NIH) at the begining and end of the study, and monitored on daily physical activity by pedometer during the study.
Results: Computerized randomization by minimization method was successful, resulting in no significant differences of major risk factors. Total of 249 residents (A: 87, B: 78, C: 84) were followed up for 12 months (follow-up rate 79%). B and C group had significant increased brisk walking than that of A group. Lipid profile was improved in all groups. Above all, HDL-C level increased by 0.31, 2.47 and 3.62 mg/dl in A, B and C groups (P<.05). Although intake of total energy and cholesterol per 1,000 kcal a day were reduced in all groups, n-3 PUFA per 1,000 kcal is significantly increased in only C groups (P<.05).
Conclusions: Brisk walking improved lipid profile, especially increase HDL-C level, which was augmented by increased intake of n-3 PUFA.