Abstract 3534: The Relation of C-reactive Protein to Chronic Kidney Disease in African Americans: The Jackson Heart Study
Background: African Americans have an increased incidence and worse prognosis with chronic kidney disease (CKD - estimated glomerular filtration rate <60 ml/min/1.73 m2) than their counterparts of European-descent. Inflammation has been related to renal disease in non-Hispanic whites, but there are limited data on the role of inflammation in renal dysfunction in African Americans.
Methods: We examined the cross-sectional relation of log transformed C-reactive protein (CRP) to renal function (by Modification of Diet and Renal Disease equation) in African American participants of the Jackson Heart Study first examination (2000 to 2004). We conducted multivariable linear regression relating CRP to renal function adjusting for age, sex, body mass index (BMI), systolic and diastolic blood pressure, diabetes, total/HDL cholesterol, triglycerides, smoking, lipid lowering therapy, hormone replacement therapy, and cardiovascular disease events.. Secondary analysis tested for effect modification by age, sex and BMI.
Results: Participants (n=4858) were 63.2% women and had a mean age ± SD of 54.8 ± 12.8 years. In the multivariable regression, CRP was higher in those with CKD compared to those without CKD (mean CRP 3.5 mg/L vs. 2.5 mg/L respectively p<0.00001). There was evidence of effect modification by sex.(p=0.0128) In men multivariable adjusted CRP was significantly higher in those with CKD compared to those without CKD (mean CRP 2.6 mg/L vs. 1.6 mg/L respectively p=0.0208). The relation between CRP and CKD was not significant in women (mean CRP 3.1 mg/L in those without CKD vs. 3.9 mg/L in those with CKD; p =0.0523).
Conclusion: CKD was associated with higher CRP concentrations in men in multivariable adjusted analyses. The question as to whether inflammation contributes to progressive renal dysfunction in African Americans merits further investigation.