Abstract 3530: Effect Of Yoga On Inflammatory Markers And Quality Of Life In Patients With Chronic Heart Failure
Background: Heart failure (HF) remains a significant cause of mortality and morbidity despite widespread use of effective pharmacological agents. Recently, physical exercise in the form of yoga has gained immense popularity. Many believe that the addition of yoga may be beneficial in cardiac rehabilitation. We hypothesized that an 8-week yoga intervention would improve symptoms of HF as reflected by exercise tolerance, quality of life (QoL), and markers of inflammation (IM) associated with heart failure.
Methods: Heart failure patients (n=19) with a New York Heart Association Class I, II, or III were randomized to treatment with yoga (YT) or standard medical therapy (MT). Both groups were given a home walk progression.
Measurements included: graded exercise test (GXT) to VO2PEAK, blood pressure, flexibility, waist/hip ratio, the Minnesota Living with Heart Failure Questionnaire (MLHFQ), and serum soluble levels of interleukin-6 (IL-6), C-reactive protein (CRP), and extra-cellular superoxide dismutase (Ec-SOD).
Results: All patients completed the yoga therapy without complication. GXT time and VO2PEAK were significantly improved in the YT group versus baseline (Table 1⇓, p3 0.002 and p=0.024, respectively). Suggesting an improvement in QoL, there was a 26% decrease in the MLHFQ in YT versus a 3% increase in MT. Compared to baseline, there were significant differences in soluble levels of IL-6 (p<0.001), CRP (p=0.002), and Ec-SOD (p=0.002) in YT.
Conclusions: Yoga appears safe to implement events in patients with chronic HF. Furthermore, yoga therapy may improve QoL, exercise tolerance and IM associated with adverse cardiovascular events in chronic HF.