Abstract 3501: Race-ethnic differences in the association between mitral annular calcification and cardiovascular events. The Northern Manhattan Study.
BACKGROUND: Previous population-based studies have documented racial disparities in incidence of vascular events, but the explanation of these disparities remains elusive. Recently, a connection between mitral annular calcification (MAC) and atherosclerosis has been documented, but there is limited data in non-Caucasian population.
METHODS: The study included 1,958 subjects of the Northern Manhattan Study (NOMAS) undergoing baseline transthoracic 2D-echocardiography. The majority of the subjects were Hispanic (57%), followed by black (23%) and white (20%). Subjects were aged ≥ 40 years at enrollment, and were free of prior myocardial infarction (MI) and stroke. Subjects were followed annually to detect MI, ischemic stroke and vascular death. The Cox proportional hazard model was used for the analysis.
RESULTS: Of 1,958 subjects, 1202 (61%) were women and the mean age was 67.9 ± 9.7 years. MAC was most prevalent in whites (38% compared to 26% in blacks and 23% in Hispanics; p < 0.001). Event rates during the median follow-up of 7.4 years for each subgroup and its association are shown in the Table⇓. After adjustment for other risk factors, MAC was significantly associated with MI in whites (HR 2.95; p = 0.018) and with vascular death in Hispanics (HR 1.85; p = 0.026).
CONCLUSION: In this older multiethnic population, the prevalence of MAC varied among different racial groups. Overall, MAC was a strong and independent predictor for MI and vascular death in this multiethnic cohort, and its impact was stronger in whites and Hispanics than in blacks.