Abstract 3452: The Common Variant Rs9939609 In The FTO Gene Is Associated With Myocardial Infarction In Two Large German Populations (German Family MI Study And KORA-B)
Very recently, a genome-wide search for type 2 diabetes susceptibility genes identified a common variant in the FTO gene that predisposes to diabetes through an effect on body mass index (BMI). The A allele of rs9939609 (frequency 39%) was associated with increased BMI with a median per-allele change of ~0.36 kg/m2. Obesity (BMI >30) is a major risk factor for cardiovascular disease, especially for myocardial infarction (MI). We aimed to identify the role of rs9939609 in two large German MI populations with markedly different ascertainment strategies. Two different MI populations were studied. The first case group (Cases A) consists of 762 MI patients ascertained by a strong family history of MI. The second case group (Cases B) included 589 patients suffering from sporadic (non familial) MI from the German KORA register (KORA-B). The control group (Controls) consisted of participants of the WHO MONICA survey in Germany (n=1,644). The genotypes were either extracted from data of a genome wide scan using the 500K Affymetrix Gene Chip Array (Cases A and Controls) or by Taqman assay (Cases B). First, there was a non-significant trend towards higher BMI in carriers of the TA or AA genotype of rs9939609 in all populations under study (table 1⇓). Second, rs9939609 was associated with MI in both MI populations (table 2⇓). Our data suggest that rs9939609 within the FTO gene is related to the risk for MI in these two large German MI study samples. The function of FTO is mostly unknown. Hence, the mechanisms underlying the association between the FTO gene product and energy balance as well as the risks of diabetes and MI are unknown and require additional investigation.