Abstract 3414: Mortality Incidence and the Severity of Coronary Atherosclerosis Assessed by CT Angiography
Objectives: This study was performed to investigate the relationship between the degree of coronary artery disease (CAD) and incidence of mortality in patients who were referred for Cardiovascular Computed Tomographic Angiography (CTA) in an outpatient setting.
Background: Non invasive coronary angiography is being increasingly performed by CTA to assess for significant obstructive CAD. While there is extensive literature on mortality incidence with respect to degree of CAD defined by conventional coronary angiography and coronary artery calcification, no such outcome data exists for coronary CTA.
Methods: We observed over a mean follow-up of 5±2 yrs, 2971 consecutive patients who underwent cardiac CTA. Significant CAD, defined as greater or equal to 50% luminal narrowing of an epicardial vessel, was determined by CTA. All cause mortality was detected through a search of the national death registry by patient’s social security number. Multivariable Cox proportional hazards models were developed to predict all-cause mortality.
Results: Among this cohort, we detected a total of 102 deaths (3.4%). We observed the following mortality rates among patients with varying degrees of atherosclerotic disease burden; 3 vessel disease 18.8% (3/16), 2 vessel disease 6.1% (6/99), 1 vessel disease 3.5% (12/347), non obstructive disease 2.1% (22/1062), no detectable disease 1.8% (15/849). Patients with increasing severity of both non-obstructive and obstructive disease were more likely to die over the subsequent 5 years (Table 1⇓).
Conclusions: The severity of coronary artery disease assessed by noninvasive CT angiography independently correlates with all cause mortality.