Abstract 3317: Secondhand Smoke Exposure Causes a Sustained Increase in Systolic Blood Pressure
Secondhand smoke (SHS) increases the risk of vascular disease and is a major public health concern. It was shown previously that SHS causes acute endothelial vasodilator dysfunction. The effects of SHS on hemodynamic parameters are not well established. We hypothesized that acute short-term exposure to real-world levels of SHS causes a sustained rise in blood pressure (BP). Healthy normotensive nonsmokers (30±3 (SEM) years, n=10) were exposed to either 30 min of SHS in a controlled exposure chamber using a standard smoke machine (total suspended particulate matter 367±43 ug/m3, nicotine 67±9 ug/m3) comparable to a bar where smoking is allowed or smoke-free air on 2 separate days. BP was measured non-invasively before exposure (baseline), immediately after (0 h) and at 1, 2.5, and 24 h. Baseline BPs and heart rate were not significantly different between study days (104±3/61±3 mmHg, 62±3 bpm). While smokefree air did not affect systolic and diastolic BP or heart rate, systolic BP significantly increased by 8.7±1.6 mmHg at 2.5 h and by 9.2±1.5 mmHg 24 h following SHS smoke exposure. Heart rate and diastolic BP remained unchanged. Even transient exposure to SHS leads to a sustained and robust rise in systolic blood pressure. These results provide further scientific evidence that involuntary SHS exposure constitutes a significant public health risk.