Abstract 3306: Impact of Renal Dysfunction on Uptake of F-18 Fluorodeoxylucose on Positron Emission Tomography in Arterial Plaques
Background: Chronic kidney disease (CKD) is an independent risk factor for atherosclerosis. Recently, it has been reported that F-18 fluorodeoxyglucose (FDG) on positron emission tomography (PET) can detect inflammation at arterial plaques. In the present study, we evaluated the relationship between renal functions and uptake of FDG in various arterial plaques.
Methods: In the present study, 365 subjects who underwent FDG-PET whole body imaging for cancer screening, but without cancer, were enrolled. Subjects were divided into 3 groups; Group 1 consisted of subjects with glomerular filtration rate (GFR) ≥90ml/min/1.73m2 (n=259), Group 2; subjects with GFR≥60 and <90ml/min/1.73m2 (n=77), Group3; subjects with GFR <60ml/min/1.73m2 (n=29). Inflammations at various vascular sites including bilateral common carotid arteries, ascending aorta, and bilateral femoral arteries were quantified by using the standard uptake value (SUV) of FDG accumulation.
Results: Mean SUV was significantly different among the 3 groups at every arterial site (see Table⇓). Univariate logistic analysis showed that GFR was significantly and well correlated with mean SUVs (common carotid arteries: r =−0.417, P<0.0001, ascending aorta: r =−0.450, P<0.0001, femoral arteries: r =−0.404, P <0.0001). In multivariable regression analysis including atherosclerotic risk factors (age, sex, diabetes, hypertension, smoking, body mass index, urea acid, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, and GFR), GFR was associated significantly and negatively with mean SUVs at various arteries (common carotid arteries: β =−0.170, P =0.0086, ascending aorta: β= −0.263, P<0.0001, femoral arteries: β =−0.148, P =0.0060).
Conclusions: GFR is independently associated with SUVs of FDG. Inflammation in systemic atherosclerosis increases in subjects with CKD.