Abstract 3199: Direct Comparison Between Gated Single-photon Emission Computed Tomography Imaging By High Speed D-SPECT And A-SPECT In The Evaluation Of Patients With Known Or Suspected Coronary Artery Disease
Background: A novel SPECT camera (D-SPECT)(Spectrum-Dynamics) has been designed to increase sensitivity as well as spatial and energy resolution. This study directly compared rest/stress myocardial perfusion SPECT (MPS) performed by D-SPECT and by dual detector Anger camera (A-SPECT)(Siemens E-Cam) in patients (pts) with known or suspected CAD.
Methods: 40 consecutive pts (age 61±12 years, 26 men) had same day rest/stress or stress only gated MPS. Images were acquired with both devices within 30 min of each other. Stress acquisitions times were 2 min and 16 min for D-SPECT and A-SPECT, respectively. Visual interpretation of MPS by the consensus of two readers used 17 segment/5 point scoring (0=normal, 4=absent) For each pt, summed stress score (SSS), summed rest score (SRS), and summed difference score (SDS) were generated. SSS≥4 was abnormal (abnl). Pearson’s coefficient (r) and Bland-Altman analysis were employed. Image quality was graded by a 5 point score (excellent to uninterpretable).
Results: By both A-SPECT and D-SPECT, the same 12 pts were abnl. Strong relationships between SSS, SRS and SDS by A-SPECT and D-SPECT were seen (r=0.97, r=0.94 and r=0.97, respectively, all p<0.0001). By Bland Altman analysis A-SPECT vs D-SPECT bias and limits of agreement were −0.175 (−3.6,+ 3.3), −0.44 (−4.1,+ 3.2) and +0.34 (−2.6,+ 3.3) for SSS (N=40), SRS (N=32) and SDS (N=32), respectively. Quality of all D-SPECT images was excellent or good. Images were excellent in 33 (82%) vs 12 (30%) of pts by D-SPECT and, A-SPECT respectively, p <0.005).
Conclusion: While highly comparable stress and rest perfusion results were observed, D-SPECT images in 1/8 time of A-SPECT showed higher image quality.