Abstract 3188: Prognosis of Elderly Patients With Severe Aortic Stenosis: Impact of the Left Ventricular Systolic Dysfunction
Background: The natural history of severe aortic stenosis (AS) in elderly remains poorly understood.
Purpose: The aim of this study was to investigate natural history of elderly patients with severe AS and to identify echocardiographic predictors of clinical outcome.
Methods: A total of 92 consecutive elderly patients aged over 80 years with severe AS (74 women and 18 men; mean [±SD] age, 86±5 years) were enrolled and studied. Cardiovascular events were defined as death, heart failure, stroke and aortic valve surgery.
Results: Clinical follow-up (17 ± 20 months) was available for 79 patients (86 %) . During follow-up, cardiovascular events were documented in 51 patients (20 death, 19 heart failure, 2 stroke and 10 aortic valve surgery). Event-free survival was 42 % at 1 year, 32 % at 2 years, and 6 % at 4 years. By echocardiography, left ventricular ejection fraction (LVEF) was significantly lower in patients with cardiovascular events than without. Event-free survival was significantly low in patients with LVEF < 50 % than in patients with LVEF ≥ 50 % (Figure⇓).
Conclusions: Patients aged over 80 years with severe AS and left ventricular systolic dysfunction are at extremely high risk for the development of cardiovascular events.