Abstract 2984: Age-Related Quality of Life and Health Status Outcomes of COURAGE Trial Patients During Long-Term Follow-Up
Purpose: The Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial randomized 2,287 chronic angina patients with stable CAD to percutaneous coronary intervention (PCI) plus optimal medical treatment (OMT) or OMT alone in a total of 50 Canadian, VA and US non-VA hospitals. The purpose of this study was to assess differences in quality of life (QOL) and health status between patients older than 65 and those 65 or younger.
Methods: There were 1,381 patients (60%) ≤ age 65 years and 904 patients (40%) > age 65 years. Quality of life was assessed with the Seattle Angina Questionnaire (SAQ) and health status with the RAND-36 at baseline, 1, 3, 6, 12 months and annually thereafter. Age and treatment group differences in SAQ and RAND-36 scores were assessed by analysis of variance (ANOVA), and linear mixed effects models.
Results: There were no significant age by treatment group interactions for any of the SAQ or RAND-36 domains at any follow-up interval (up to 5 years) for patients who were randomized to the PCI + OMT vs. the OMT strategy, indicating that overall QOL and health status were similar for both age groups. Younger patients had significantly higher Physical Functioning mean scores whereas older patients had significantly higher QOL mean scores and emotional well-being scores. (Figure 1⇓). RAND-36 domains followed similar trends of increase in mean scores from baseline to 3– 6 months.
Conclusions: Age did not affect PCI vs. OMT differences in quality of life and health status functioning. Older CAD patients experienced poorer physical functioning, but better overall quality of life than younger patients.