Abstract 2939: Women with Pregnancy induced Hypertension have an increased incidence of Hypertension and Cardiovascular events in future
Introduction: Studies suggest that pregnancy induced hypertension is associated with a higher incidence of hypertension in the later life. We investigated whether there is a relationship between hypertension in pregnancy and the subsequent incidence of hypertension and cardiovascular events (Including Ischemic deaths, MI, revascularisation, Ischemic heart failure, Stroke, TIA).
Methods: The current cardiovascular and hypertension status of 200 women with a history of pregnancy-induced hypertension was compared with that of 100 women delivered during the same period in the past. Data from this index pregnancy including age, family history Ischemic Heart Disease, Diabetes Mellitus, Smoking, BMI and blood pressure was collected. Direct contact, questionnaire and general practitioner and hospital records established current cardiovascular status.
Results: These women were followed up over a mean period of 15 years (range 11–20 years). There was no significant difference between the mean age of the women (43 years, range 37–50 Years) in the two groups. Incidence of hypertension (51/197 vs 11/100, p<0.001) and Cardiovascular events (26/200 vs. 4/100, p<0.003) was significantly higher in women with pregnancy-induced hypertension compared with normotensive pregnancy. Using a multivariate binary logistic model (age, hypertension in pregnancy, Smoking, Diabetes, family history of IHD), pregnancy induced hypertension (OR4.74, 95% CI: 1.34 –16.72, p<0.015) and smoking (OR4.40, 95% CI: 1.4 –13.62, p<0.010) were the only significant independent predictors of future cardiovascular events.
Conclusion: Pregnancy induced hypertension is associated with increased future risk of hypertension and cardiovascular events