Abstract 2795: Association of Increased Plasma Cardiotrophin-1 with Inappropriate Left Ventricular Mass and Cardiac Dysfunction in Essential Hypertension
Background- iLVM, as defined by observed LVM values exceeding levels predicted by its major physiologic determinants, has been reported to be associated with cardiac dysfunction in hypertensive patients Objective- To investigate whether plasma concentration of cardiotrophin-1 (CT-1), a cytokine that induces cardiomyocyte hypertrophy and dysfunction, is related to inappropriate left ventricular mass (iLVM) and cardiac dysfunction in hypertensive patients.
Methods- One hundred and eighteen patients with never-treated essential hypertension and without prevalent cardiac disease were included. The LVM prediction from stroke work (systolic blood pressure × Doppler stroke volume), sex, and height (in meters2.7) was derived. Observed LVM/predicted LVM>128% defined iLVM. Plasma CT-1 was measured by an enzyme-linked immunosorbent assay.
Results- Forty-three percent of patients exhibited iLVM. Patients with iLVM exhibited echocardiographic features of systolic and diastolic dysfunction. Plasma CT-1 was higher (P<0.001) in hypertensive patients with iLVM than in hypertensive patients with appropriate LVM and normotensive controls. A direct correlation was found between CT-1 and observed LVM/predicted LVM ratio (r=0.330, P<0.001) in all hypertensive patients. This association was independent of potential confounding factors. Significant associations were found between abnormally high levels of CT-1 and the presence of iLVM, systolic and diastolic dysfunction in all hypertensive patients.
Conclusions- Albeit descriptive in nature, these results suggest the hypothesis that an excess of CT-1 may contribute to inappropriate LV growth and dysfunction in hypertensive patients.