Abstract 2733: A Common Kinesin Family Member 6 (KIF6) Variant is Associated with Coronary Heart Disease in the Women’s Health Study
Kinesins are a family of proteins involved in intracellular transport. A variant of kinesin family member 6 (rs20455, Trp719Arg) has been reported to be associated with coronary heart disease (CHD) in the Atherosclerosis Risk in Communities (ARIC) study, and the placebo arms of the Cholesterol and Recurrent Events Study (CARE) and the West of Scotland Coronary Prevention Study (WOSCOPS). To validate and extend these observations, we genotyped the KIF6 Trp719Arg SNP among 24,794 initially healthy Caucasian women, age 45 and over, participating in the Women’s Health Study. During an average follow-up of 10 years, 865 women suffered a first ever myocardial infarction, ischemic stroke coronary revascularization, or cardiovascular death. The risk associated with the 719Arg allele of KIF6 was estimated using Cox proportional hazards models adjusted for traditional risk factors. Both CHD and myocardial infarction events were more frequent in carriers of the KIF6 719Arg allele than in noncarriers (Figure⇓). Compared to noncarriers, carriers of the 719Arg allele had an increased risk of CHD [adjusted hazard ratio=1.30 (95% CI 1.07–1.57, p=0.007)] and myocardial infarction [adjusted hazard ratio=1.38 (95% CI 1.03–1.85, p=0.033)]. There was no association between the 719Arg allele and the risk of ischemic stroke. In conclusion, in a large prospective cohort of initially healthy women, the KIF6 719Arg allele was confirmed to be associated with increased risk of CHD and myocardial infarction.