Abstract 2694: Persistent Elevated E/E’ Predicts Prognosis In Congestive Heart Failure Patients With Preserved Systolic Function
Background: Although about a half of the heart failure patients has been reported as heart failure with preserved left ventricular systolic function (HFPSF), echocardiographic prognostic predictors have not been well investigated. Recently, tissue Doppler derived index, E/E’, has been reported as useful in predicting prognosis in patients with heart diseases.
Purpose and Methods: To investigate whether E/E’ predicts prognosis in HFPSF, 50 patients with HFPSF (ejection fraction >50%) were enrolled and studied. Echocardiographic examination was performed on admission and repeated after optimized medical therapy. Cardiac events were defined as death and unplanned hospitalization due to congestive heart failure.
Results: Cardiac event-free survival curves from patients with E/E’ > 15 and E/E’ ≤ 15 at baseline did not differ. On the other hand, patients with E/E’ > 15 at follow-up showed significantly lower cardiac event-free survival than in patients with E/E’ ≤ 15 at follow-up (log-rank, p=0.005). By multivariate logistic regression analysis, E/E’> 15 at follow-up was the only independent predictor of cardiac events (p=0.037, RR=6.1, 95% CI: 1.12–33.3) in patients with HFPSF.
Conclusion: In conclusion, persistent elevated E/E’ may be useful in predicting cardiac events in patients with HFPSF.