Abstract 2643: The Effects of Statin Therapy on Ventricular Tachyarrhythmias - A Meta Analysis
Objectives: To assess whether statin therapy is associated with a reduction in ventricular tachyarrhythmias.
Background: Statins have been shown to be beneficial beyond their cholesterol-lowering effects. These pleiotropic effects have been implicated in the protection against atrial fibrillation and the reduction in appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with coronary artery disease (CAD). This meta-analysis was conducted to evaluate whether statins were associated with a reduction in ventricular tachyarrhythmias in patients with CAD or non-ischemic cardiomyopathy.
Methods: The Medline and Cochrane databases were searched from 1966 to April 2007 for English language, prospective, randomized studies looking into the association between the use of statins and the incidence of ventricular tachycardia/ventricular fibrillation (VT/VF). The occurrence of ventricular arrhythmias was defined as the VT/VF occurrence or appropriate ICD therapy for VT/VF.
Results: Of the 133 identified articles, 10 prospective randomized studies with 34,794 patients enrolled met our inclusion criteria and were included in this analysis. Using a random effects model, statin therapy was associated with a 26% reduction in the risk of VT/VF when compared to the group not on statin therapy (Pooled RR=0.94; 95% CI, 0.59 – 0.91; P=0.005; Heterogeneity χ2 =30.02; P<0.0001). There was no publication bias in this analysis (Egger’s test P=0.687).
Conclusion: Statin use in patients with CAD or non-ischemic cardiomyopathy is associated with a 26% reduction in the development of ventricular tachyarrhythmias.