Abstract 2460: Dermal Filler Injection: A Novel Approach for Preventing Infarct Expansion and Ventricular Remodeling
Objectives Infarct stretching early after myocardial infarction promotes adverse remodeling and is associated with poor long-term prognosis. We hypothesized that thickening the infarcted territory of the LV wall by means of intramyocardial injection of a hydroxyapatite-based dermal filling material would attenuate infarct expansion and improve regional contractile function within remote regions of the LV.
Methods Fifteen adult male sheep underwent coronary ligations to create an anteroapical myocardial infarction followed by injection of 1.3 mL of the hydroxyapatite based preparation into the infarcted territory. Rt-3DE was performed at baseline, 30 minutes after MI and 30 minutes after intramyocardial injection. Time-normalized volume-time curves were then constructed for the apical (ASE segments 13–17), middle (ASE segments 7–12) and basal (ASE segments 1–6) regions of the LV - regional EDV, ESV and EF were then calculated after which the individual curves were merged into hybrid regional curves representing the entire cohort.
Results Regional EDV (Panel A), ESV (Panel B) and EF (Panel C) at each of the three observation intervals are summarized in the accompanying figure⇓ (mean ± SEM; *p<0.05 compared to baseline; †p<0.05 compared to post-MI value) as are each of the hybrid regional time-volume curves (mean ± SEM). Attenuated apical (Panel D) systolic bulging is apparent following injection as is improved contractile function within the middle (Panel E) and basal (Panel F) regions of the LV.
Conclusions Injection of an acellular hydroxyapatite based dermal filler preparation reduces infarct expansion, limits LV remodeling and improves EF early after anteroapical MI.