Abstract 2369: Adherence To A Dash-style Diet And Risk Of Coronary Heart Disease And Stroke In Women
The DASH diet has been shown to lower blood pressure but little is known about its long-term effect on cardiovascular endpoints. Therefore, we prospectively assessed the association between a DASH-style diet adherence score and risk of coronary heart disease (CHD) and stroke in the ongoing Nurses Health Study cohort. Female nurses (N=88,517) aged 34 –59 without history of cardiovascular disease or diabetes in 1980 were included. Diet was assessed 5 times during 22 years of follow-up beginning 1980 using validated food frequency questionnaires during follow-up. A DASH score based on 8 food and nutrient components (fruits, vegetables, whole grains, nuts and legumes, low-fat dairy, red and processed meats, sweetened beverages, and sodium) was calculated. Lifestyle and medical information was collected biennially with a questionnaire. Cox proportional hazard model was used to adjust for potential confounders. We documented 1867 cases of incident nonfatal myocardial infarction and 883 CHD deaths and 1977 cases of stroke. After adjustment for age, smoking, and other cardiovascular risk factors, the RRs of CHD across quintiles of the DASH score were 1.0, 0.99, 0.85, 0.86, and 0.71 (95% CI 0.62– 0.82), p for trend < 0.0001. Magnitude of risk reduction was similar for non-fatal myocardial infarction and fatal CHD. The DASH score was also significantly associated with lower risk of stroke (multivariate RRs across quintiles of the DASH score were 1.0, 0.94, 0.91, 0.88, and 0.79, p for trend =0.001). Cross-sectional analysis in a subgroup of women with blood samples showed the DASH score was significantly associated with lower plasma levels of C-reactive protein (p for trend = 0.008) and Interleukin-6 (p for trend = 0.04). In conclusion, adherence to the DASH diet is associated with a lower risk of CHD and stroke among middle-aged women during 22 years of follow-up.