Abstract 2229: Incidence and Outcome of Out-of-Hospital Cardiac Arrest in a Large Population-Based Cohort. Observations from the Resuscitation Outcome Consortium
INTRODUCTION: The true incidence and outcome of out-of-hospital cardiac arrest (OOHCA) are unknown. Accurate estimation of these burdens are essential to evaluating progress towards improving public health by reducing cardiovascular disease (CVD).
HYPOTHESES: The incidence and outcome of OOHCA, emergency medical services (EMS)-treated OOHCA and ventricular fibrillation/ventricular tachycardia (VF/VT) are uniformly distributed across regions.
METHODS: Design-Population-based cohort study. Setting- 10 US and Canadian sites. Population-Non-traumatic OOHCA from 12/1/2005 to 11/31/2006, evaluated by organized EMS personnel and: received attempts at defibrillation by lay responders or emergency personnel, or chest compressions by EMS personnel; or were pulseless. Analyses- Incidence, known mortality, known case-fatality and known survival rates were standardized to the North American population after adjusting for age and sex. Multiple imputation was used to estimate values in agencies that had missing cases. Differences between sites were assessed with asymptotic chi2 tests.
RESULTS: Included were n=17,486 cases. Age was mean 64.7 + SD 19.4 years; 62.8% were male. Overall mean and range of site means were reported for incidence and outcome (Table⇓.) Incidence and outcome of OOHCA differed significantly across sites (p<0.001 within all groups.) Results were sensitive to the initial rhythm and proportion of OOHCA with known vital status at discharge.
CONCLUSIONS: OOHCA is common and lethal. Incidence and outcome of OOHCA differ significantly by geographic region. Additional investigation is necessary to understand and reduce this regional variation.