Abstract 2183: Ageing is Associated with Greater Dyssynchrony in Asymptomatic Participants of the Multi-Ethnic Study of Atherosclerosis (MESA)
Background: Myocardial dyssnychrony can cause an ineffective myocardial contraction in patients with CHF. Ageing is associated with increased risk of CHF. Yet, the relationship between dyssynchrony and age has not been studied in asymptomatic individuals. Our aim was to study the relationship between age and the magnitude of dyssynchrony expressed as the variability in the timing of regional deformation.
Methods: Regional LV function has been studied using tagged MRI in 1,100 consecutive asymptomatic participants of the Multi-Ethnic Study of Atherosclerosis with no history of cardiovascular disease (age: 45–84 years old). Timing of peak systolic strain and systolic strain rate was determined in four regions (septum, anterior, lateral and inferior wall) in three short axis slices. The magnitude of dysynchrony of myocardial function was determined as the standard deviation (SD) of time to peak strain and peak strain rate among 12 LV wall segments. The relationship between age and myocardial dyssynchrony was determined after adjustment for gender, ethnicity, BMI and risk factors including hypertension, diabetes, smoking, hyperlipidemia, and treatment for hypertension.
Results: (Table 1⇓) Importantly, age was associated with greater SD of time to peak strain and peak strain rate, indicative of greater dyssynchrony (after multivariate adjustment RC=0.33 ms/year, p=0.002, and RC=0.15, p=0.045, respectively). Increased age was also associated with longer average time to peak strain (regression coefficient (RC) after multivariable adjustment was 0.49 ms/year, (95% CI= 0.14–0.86, p=0.007). There was no significant relation between age and time to peak systolic strain rate.
Conclusion: Among asymptomatic individuals, increased age is associated with greater dyssynchrony and delay of regional myocardial contraction. Greater age related dyssynchrony may represent an important factor contributing to the higher occurrence of CHF among the elderly.