Abstract 2024: The Relation of Mean Platelet Volume to Paroxysmal Atrial Fibrillation: A Predictive Marker?
Background: Etiology of atrial fibrillation is multifactorial. Mean Platelet Volume (MPV) is a marker of platelet size, function, and activation. Active and large platelets release more thromboxane A2 than small ones. Increased MPV may be an expression of an inflammatory condition. We hypothesized that MPV is elevated in patients with paroxysmal atrial fibrillation (PAF) and studied whether increased MPV level has an association with its occurrence.
Methods: The study population comprised 66 consecutive patients who were detected to have PAF by 24-hour Holter monitoring (HM) and 54 control individuals with no PAF on HM. All patients underwent echocardiography and MPV was routinely measured. Comprehensive clinical data were collected. Patients with aortic and mitral stenosis, hyperthyroidism, hypothyroidism, and pregnancy were excluded from the study.
Results: Mean age of the patients was 56±8 vs. 54±9 years (p=0.12) in PAF and control groups, respectively. Twenty eight (42%) in PAF and 16 (29%) (p=0.14) patients in control group were male subjects. MPV was significantly higher in PAF group when compared to control subjects (9.9±2.3 fl vs. 8.3±1.2 fl, respectively; p<0.001). There was no difference in white blood cell and platelet counts, C-reactive protein and erythrocyte sedimentation rate between two groups. In a multivariate analysis that included use of acetyl salicylic acid/clopidogrel, left ventricle ejection fraction, and mitral regurgitation; elevated MPV along with left atrial diameter predicted the occurrence of PAF.
Conclusion: Our results indicate that MPV is elevated in patients with PAF.