Abstract 1826: Long-term Prognosis of Subjects with Brugada-type Electrocardiogram Diagnosed during a Health Examination
BACKGROUND: There are few population-based studies of Brugada-type ECG with a long follow-up period. The objective of the present study was to assess a long-term prognosis of the subjects diagnosed to have Brugada-type ECG during a health examination.
METHODS: We studied 13,904 subjects (mean age 58±10 years, men 27%) who had the annual health examination including an ECG recording offered to adult citizens of Moriguchi city, Osaka, Japan in 1997. The end of follow-up was the end of 2005. Proportional hazards regression analyses were performed to compare the difference in all cause and cardiovascular mortality between the subjects with and without Brugada-type ECG. Clinical variables used in the adjusted model were age, gender, smoking, hypertension, diabetes mellitus, drinking habit, and body mass index.
RESULTS: The Brugada-type ECG was found in 98 subjects (mean age 58±9 years, men 81%) with 38 % of type 1. During a mean of 7.8±1.6 years (median 8.2 years), there were 4 deaths (4.1%) and 1 cardiovascular death (1.0%) among the subjects with Brugada-type ECG, whereas 612 deaths (4.4%) and 142 cardiovascular deaths (1.0%) among those without Brugada-type ECG (Table⇓). There were no subjects with Brugada-type ECG who received implantable cardioverter defibrillator. Not only unadjusted but also adjusted proportional hazards regression analysis showed no significant difference in cardiovascular or all cause mortality between subjects with and without Brugada-type ECG. One cardiovascular death of subjects with Brugada-type ECG was sudden with autopsy in which there was no finding of myocardial infarction. He was 56 year old and had a type 2 morphology.
CONCLUSIONS: Brugada-type ECGs diagnosed during health examination are not associated with increased risk of either cardiovascular or all cause mortality.