Abstract 1725: Long Pentraxin3 (PTX3) is More Specific than CRP as a Marker for Vascular Inflammation
Background - C-reactive protein (CRP) is an established marker to predict cardiovascular events. The long pentraxin 3 (PTX3) shares structural homology with CRP and is produced abundantly by vascular endothelial cells and macrophages while CRP is mainly produced in the liver. Thus PTX3 is expected to be a more specific marker for cardiovascular inflammation.
Method and Results - We established a high sensitivity assay method for PTX3, and examined plasma PTX3 and serum CRP levels in 259 consecutive patients who underwent coronary angiography (20 to 89 years old age, 74.9 % male). The correlation between the concentrations of PTX3 and CRP was substantially weak (Spearman’s ρ=0.117), suggesting that PTX3’s induction manner was distinct from that of CRP in clinical setting. Notably, PTX3 levels in patients taking statins or aspirin were lower than non-taking patients. Although both PTX3 and CRP levels were higher in the unstable angina pectoris (UAP) group than the stable angina and normal coronary groups, only PTX3 was statistically significant (as shown in Figure⇓). In multivariable logistic regression analysis, both CRP and PTX3 were independently associated with UAP. Moreover PTX3’s association was statistically stronger than that of CRP. Finally PTX3 didn’t show any apparent correlation with the severity of coronary atherosclerosis evaluated by the modified Gensini score.
Conclusion - Plasma PTX3 levels were elevated in UAP patients. PTX3 may reflect active inflammation that leads to plaque rupture more specifically than CRP.