Abstract 1719: Plaque Composition at Sites of Focal Coronary Spasm in Patients with Vasospastic Angina: a study with intravascular ultrasound radio frequency data analysis
Background: There is no data about the intravascular ultrasound radiofrequency findings in patients with vasospastic angina. The purpose of this study is to assess plaque compositions at the sites of focal coronary spasm.
Methods and Results: Total 28 patients, 38 to 65 years of age, with minimal coronary lesions were included in this study. The patients were divided into two groups; 13 patients (Group 1) with angina in whom epicardial focal coronary spasm was provoked by intracoronary ergonovine and 15 patients (Group 2) without vasospasm. Coronary plaque tissue maps were reconstructed from radiofrequency data using IVUS-Virtual Histology software. The percentage of lipid core and calcium was significantly lower in the group 1 when compared with the group 2 (10.46±8.05% vs 20.53±8.93%, p=0.004, 5.15±5.32% vs 10.00±7.01%, p=0.048). However, the percentage of fibrous tissue was larger in group 1 than group 2 (70.31±11.29% vs 60.33±9.36%, p=0.019). Total plaque volume, lesion length, and plaque burden were not different between group 1 and group 2 (127.56±44.58mm3 vs 129.64±41.97mm3, p=0.90, 16.71±4.59mm vs 19.41±4.51 mm, and p=0.13, 54.31±7.69% vs 58.87±2.99%, p=0.063, respectively).
Conclusions: Patients with vasospastic angina have less necrotic core and calcium at the site of focal coronary spasm compared with patients without vasospasm, even though the plaque volume and plaque burden were similar in both groups.