Abstract 1703: Urinary 8-Hydroxy-2′-Deoxyguanosine Level reflects symptomatic status and severity of systolic dysfunction in Patients with Chronic Heart Failure
Background: Oxidative stress has been implicated in the pathogenesis of chronic heart failure. However, there is little information as to whether or not either symptomatic status or severity of systolic dysfunction correlates with the level of urinary 8-hydroxy-2-deoxyguanosine (U-8-OHdG), a marker of oxidative DNA damage, in patients with chronic heart failure (CHF).
Methods: In a preliminary study, blood sampling from both coronary sinus and artery showed that cardiac tissue produced 8-OHdG in patients with severe CHF, suggesting that U-8-OHdG may be suitable for evaluation of severity of CHF because of convenience. Therefore, we measured U-8-OHdG in 30 control subjects (no prior clinical history of HF or LV dysfunction, age and gender-matched) and 80 patients with CHF (mean age: 53±18 years; male: 60%; LVEF: 28±18%, DCM: 50%; DHCM: 20%; cardiac sarcoidosis: 20%; ICM: 10%). Then, we examined the relationship between U-8-OHdG and LVEF, PCWP, or plasma BNP.
Results: In our cohort, U-8-OHdG (ng/ml) in patients with CHF was higher than that of control subjects (Control vs CHF: 6.8±1.9 vs 14.6±9.2, p<0.01). The mean value of U-8-OHdG increased in parallel with an increase in NYHA class (see figure⇓), with a significant correlation between U-8-OHdG and LVEF (r=−0.4, p=0.004), PCWP (r=0.45, p=0.03), or serum BNP (r=0.38, p=0.015.).
Conclusions: U-8-OHdG seems to reflect well the clinical severity based on both symptom and cardiac dysfunction in CHF, suggesting that the level of U-8-OHdG is a clinically useful marker for the evaluation of severity of CHF.