Abstract 1627: Relationship Between CD34+AC133+CD45low Endothelial Progenitor Cells and Cardiovascular Risk Factors
Growing evidence suggest that circulating endothelial progenitor cells (EPCs) contribute to postnatal neovascularization and reendothelialization in adult vessels. The number of EPCs in peripheral circulation could be reflected in pathogenesis of atherosclerosis and progression of cardiovascular diseases, which is useful as a surrogate biologic marker for atherosclersis. We examined the relationship between circulating EPCs and cardiovascular risk factors. Circulating EPCs in peripheral blood were measured by flow cytometry as CD34+/AC133+ /CD45low cells in consecutive 122 patients with cardiovascular diseases, and 36 healthy subjects. The number of EPCs inversely correlated with the number of risk factors (R=−0.443, P<0.0001). In multivariate analysis age and hypertension are identified as an independent predictor for reduced EPCs number.