Abstract 1511: Trends in Gender Difference in Mortality after Acute Myocardial Infarction
Objective: This study was undertaken to investigate trends in gender difference in mortality of patients with acute myocardial infarction (AMI).
Background: Previous studies have reported that women patients with AMI had higher mortality than men. Recent progress in management of AMI might have changed the effect of gender on mortality after AMI.
Methods: Between 1981 and 2002, consecutive 1,984 patients with AMI underwent coronary angiography within 24 hours after the onset of symptom. They were divided into 3 groups in the chronological order: group I (1981– 88, n=564), group II (1989–95, n=678) and group III (1997–2002, n=742).
Results: Thrombolysis was most frequently performed in group I (50%) and coronary intervention in group II (73%) and in group III (85%): coronary stents were used in 77% of group III. There were 405 women (20%), who were associated with higher age, more diabetes, more hypertension, less current smokers and less previous infarction than men. 3-year mortality was significantly higher in women than in men in group I (27% vs 18%, p=0.03) and group II (23% vs 15%, p=0.048) (Figure⇓). In group III, there was no significant difference in 3-year mortality (12% vs 10%, p=0.66) between women and men. Multi-variable analysis showed that sex was not an independent predictor of 3-year mortality in the 3 groups.
Conclusion: In the contemporary era, women with AMI who were treated mostly with primary intervention using stents had similar mortality as men.