Abstract 4203: Resting Heart Rate and its Changes Over Years as a Risk Factor for Mortality in the General Population: The Paris Prospective Study I
Background: Whether resting heart rate (HR) is a risk factor for mortality remains discussed. The aim of the study was to investigate whether HR changes are related to mortality in the population.
Methods: 4320 native Frenchmen aged 42 to 53 years were recruited between 1967 and 1972, and had yearly examinations during the next 5 years in the same standardized conditions. Subjects had electrocardiograms and physical examinations conducted by a physician, provided blood samples for laboratory tests, and answered questionnaires administered by trained interviewers. Resting HR was determined by measurement of the radial pulse during a one-minute recording, after a five-minute rest in supine position.
Results: During the follow-up period (> 20 years) 1018 men died. Subjects were divided into 9 groups according to their baseline HR (≤ 60 bpm , 61–75, and > 75 bpm) and to HR variation between baseline and the 5th examination (decrease > 7 bpm, low variation ie between − 7 and +7 bpm, and increase > 7 bpm). Relative risks of mortality were estimated by Cox model after adjustments for age, physical activity, tobacco consumption, body mass index, systolic blood pressure, glycemia, and total cholesterol. Compared to the reference group (baseline HR between 61 and 75 bpm and low variation at the 5th examination), baseline HR but also changes over years were both associated with the risk of death (table⇓).
Conclusion: Our results show that resting HR and its changes are independent risk factors of mortality in the general population.