Abstract 4181: The Age and Gender Related Patterns of Insulin Resistance in UK Indian Asians and Northern Europeans: the London Life Sciences Population (LOLIPOP) Study
Background Insulin resistance is a risk factor for cardiovascular disease (CVD). Previous studies have demonstrated that insulin resistance is more common in Indian Asians (IA) compared to Northern Europeans (NE). We report the age and gender related prevalence of insulin resistance, and related metabolic disturbances among IA and NE in the London Life Sciences Population (LOLIPOP) Study.
Methods The LOLIPOP study is a population based study of IA and NE men and women aged 35–75 years, identified from the lists of 58 primary care physicians in West London. To date 19,272 participants (IA: 8791 male, 4013 Female; NE: 4346 male, 2122 female) have been recruited, with a response rate of 61%. Clinical and anthropometric data and measurements of fasting insulin, glucose, triglycerides and HDL cholesterol were recorded for each subject. Metabolic Syndrome (MS) was defined using Adult Treatment Panel III criteria.
Results Waist-hip ratio, fasting insulin, glucose and triglycerides were higher, and HDL cholesterol lower, amongst IA compared to NE (all P<0.001). Blood pressure was similar in IA and NE. The prevalence of MS was higher in IA than NE at each age studied (Figure⇓). Compared to NE, the age-adjusted prevalence of metabolic syndrome was 41% greater in IA men and 140% greater in IA women.
Conclusions Our results show striking differences in age and gender related disturbances of insulin action in IA compared with NE. MS appears to develop almost 10 years earlier amongst IA men, and 20 years earlier amongst IA women, compared to NE men and women respectively. Follow-up of this cohort will help to determine the extent to which these differences contribute to higher cardiovascular events in IA.