Abstract 4177: High Serum Dehydroepiandrosterone Sulfate Levels are Strikingly Associated with Less Mortality in Men: 27-Year Follow-Up Study
Background: Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are secreted adrenal steroids. DHEAS concentrations decline with aging. Supplementary use of DHEAS is common nowadays with a hope of longevity. But, there has been no data available. We investigated whether DHEAS levels could predict survival in humans.
Methods: A total of 940 subjects (396 men, 544 women), aged 21 to 88, underwent a health examination in a community-based cohort in 1978–1979. In all subjects, baseline DHEAS measured by radioimmunoassay, and they were followed until 2005.
Results: DHEAS levels were higher in men than in women and decreased with aging in both sexes. In a Cox proportional hazards model, age, DHEAS (inversely), systolic and diastolic blood pressure, and fasting plasma glucose were significantly associated with mortality in men. Of these variables, elevated DHEAS levels were the strongest predictor of survival after adjustments for age, systolic blood pressure, and fasting plasma glucose. Although elevated DHEAS levels were significantly related to survival in women, the significance disappeared after adjustment for age. DHEAS levels in men were classified into tertiles: group1 <130, group2 130≤-<200, group3 ≥200 ng/ml. Only 74.4% of subjects in the lowest DHEAS tertiles survived compared with more than 93.4% in the highest DHEAS tertiles, after adjustments for age and possible confounding factors (Hazard ratio:0.206; 95%C.I. 0.067– 0.630, p<0.01).
Conclusions: This study is the first demonstration of the favorable effect survival on a DHEAS in men in a 27-year prospective study.