Abstract 4176: No Protection Against New Cardiac Events of a High Omega-3 Index in Patients Presenting with an Acute Coronary Syndrome
Objectives: Previous studies evaluating the association between n-3 fatty acids (FAs) and coronary heart disease suggest that their main effect might be a reduction in the risk of fatal myocardial infarction (MI) and sudden death. This protective effect seems to be related to a direct stabilizing effect of n-3 FAs on the myocardium itself. Red blood cell EPA + DHA (expressed as percent of total FAs; the Omega-3 Index) has recently been found to be a good surrogate for the cardiac content of omega-3 FAs and may serve as an independent risk factor for cardiac events. We examined the long-time prognostic value of the Omega-3 Index in a coastal population surviving an acute coronary syndrome (ACS).
Methods: The Omega-3 Index was measured at admission in 466 patients hospitalized with ACS. During a follow-up time of two years, recurrent MI (defined as a TnT > 0.05 with a typical MI presentation) and all-cause mortality was registered. Odds ratios (OR) for new events were computed across quartiles of the Omega-3 Index; Q1 < 5.24 %, Q2 [5.24- 6.385 %], Q3 [6.385–7.89 %] and Q4 ≥ 7.89%.
Results: Follow-up event-rates are given in Table 1⇓. Comparing Q4 to Q1 the univariate analysis gives an OR of 1.03 (p = 0.787) for re-MI, 0.90 (p= 0.328) for all-cause mortality and 0.95 (p= 0.556) for the combined endpoint of re-MI and/or death after two years of follow-up.
Conclusion: A high Omega-3 Index had no protective effect against new cardiac events and/ or death in this cohort of Norwegian ACS patients. This might be related to the very high intake of fish in this costal population, with the level of n-3 FAs exceeding a threshold limit beyond which no further protection can be demonstrated.