Abstract 4175: Isoflavone Does not Acutely Alter Endothelial Function in Patients with Cardiovascular Diseases
Introduction: Prior in-vitro studies demonstrated a stimulatory effect of isoflavone on the endothelial nitric-oxide synthase system within a period of 48–96 hours, and may lead to an improvement in vascular endothelial function. However, the acute effect of high dose intake of isoflavone on endothelial function in patients (pts) with cardiovascular disease remains unclear.
Methods: We studied the effect of high dose intake of isoflavone on vascular endothelial function in pts with cardiovascular diseases. 32 pts with ischemic stroke were randomized to receive either 80mg/day isoflavone (n=15) or placebo (n=17) for 3 days. Brachial endothelial function was assessed to determine flow-mediated dilation (FMD) and nitroglycerin-mediate dilation (NMD) at baseline and after treatment using high resolution ultrasound.
Results: As shown in Table⇓, there were no significant differences in the mean changes in heart rate, systolic (SBP) and diastolic blood pressure (DBP) in both groups. Furthermore, there were no significant changes in FMD and NMD after 3 days treatment of isoflavone
Conclusion: High dose intake of isoflavone (80mg/day) does not acutely alter vascular function in patients with ischemic stroke.