Abstract 4147: Investigation of the Relationship Between Type 2 Diabetes and Left Ventricular Function in Men and Women Aged 35–75 Years
Background: Left ventricular (LV) dysfunction is more common in patients with type 2 diabetes (T2D). Whether LV dysfunction is a specific manifestation of T2D, or is a consequence of associated hypertension, obesity, dyslipidemia or atherosclerosis remains to be determined.
Methods: 453 men and women aged 35 to 75, without clinical atherosclerosis were randomly recruited from the London Life Sciences Population (LOLIPOP) Study. Participants underwent 2D echocardiography, tissue Doppler imaging and carotid duplex scan. Systolic function parameters included left ventricular ejection fraction (LVEF) and mitral annular S wave (longitudinal function). Diastolic parameters included Doppler mitral E/A, annular e’wave, ratio of E/e’, isovolumic relaxation time (IVRT) and left atrial volume index (LAVI). Carotid intima media thickness (CIMT) was also measured.
Results: Mean age of participants (80% male) was 51±10years, and the prevalence of T2D was 14%. T2D was associated with LV mass index, mitral E/A, annular e’ wave, E/e’ and CIMT (P<0.05, table⇓). After adjusting for age, sex, cholesterol, history of hypertension, blood pressure, and body mass index, only mitral E/e’ (P=0.001) remained significantly associated with T2D.
Conclusion: T2D is associated with LV dysfunction, but some of the relationships may be accounted for by recognized risk factors. However, mitral E/e’ a marker of diastolic dysfunction, was independently associated with T2D, possibly indicating a separate effect of T2D on cardiac function.