Abstract 4144: Physical Activity and Risk of Type 2 Diabetes in UK Indian Asian and Northern European Subjects in the London Life Sciences Population (LOLIPOP) Study
Background The prevalence of Type 2 Diabetes (T2D) is four-fold higher amongst UK Indian Asians (IA) than Northern Europeans (NE). Previous studies suggest that physical activity influences risk of T2D in Caucasian populations. We have examined the contribution of physical activity to the high prevalence of T2D in IA compared with NE, among participants in the London Life Sciences Population (LOLIPOP) Study.
Methods The LOLIPOP study is a population based study of IA and NE men and women aged 35–75 years, identified from the lists of 58 GPs in West London. To date 19,272 participants (IA: 8791 male, 4013 Female; NE: 4346 male, 2122 female) have been recruited, with a response rate of 61%. Clinical and anthropometric data and measurements of fasting glucose and lipid profile were recorded for each subject. Leisure time physical activity was scored in minutes per week for vigorous (>6 METS) and moderate (3– 6 METS) activity.
Results T2D prevalence was higher, and physical activity levels were lower in IA than NE (table⇓). Higher physical activity was associated with lower risk of T2D independent of age and sex in both ethnic groups. Numerically, a 120 minutes per week higher level of moderately vigorous leisure-time physical activity was associated with 23% (CI 15–30) lower risk of T2D, in both ethnic groups. After adjustment for age and gender, T2D was 3.6 fold more common in IA than NE. The risk of T2D remained 3.4 fold higher amongst IA compared to NE, after additional adjustment for the difference in leisure time physical activity between the populations.
Conclusions The prevalence of T2D is four-fold higher in IA than NE. Physical activity levels are lower in IA than NE, and physical inactivity is associated with increased risk of T2D. Although physical activity may ameliorate the increased risk of T2D in high risk IA, physical inactivity does not account for the increased risk of T2D in IA compared with NE.