Abstract 4132: Do N-3 Polysunsaturated Fatty Acids Reduce Risk of Sudden Cardiac Death and Ventricular Arrhythmias? A Meta-analysis of Randomized Trials
Introduction: N-3 polyunsaturated fatty acids (PUFA) have been demonstrated to have antiarrhythmic properties. However, randomized studies have shown inconsistent results.
Objective: We performed a meta-analysis to analyze the effect of PUFA in preventing potential fatal ventricular arrhythmias and sudden death.
Methods: Trials published in English language journals were retrieved by searching Medline (1990 to 2006), bibliographies, and the authors’ reference files. Randomized trials comparing PUFA to placebo and reporting sudden cardiac death or first implanted cardioverter-defibrilator (ICD) event for ventricular tachycardia or fibrillation were included in the analysis. Information on sample size, treatment type, baseline characteristics and outcome were extracted using a standardized protocol. Meta-analysis using a fixed effects model was performed and results were expressed in terms of Odds Ratio (OR) and 95% Confidence Interval (CI) after evaluating for interstudy heterogeneity using I2. The reported data were extracted on the basis of the intention-to-treat principle.
Results: A total of 14,372 patients were included in 8 trials; 7,137 patients received PUFA and 7,235 received placebo. When compared PUFA to placebo, PUFA was associated with a significant risk reduction of sudden death or ventricular arrhythmias (OR=0.81, [95% CI: 0.68, 0.96], p=0.02 I2 =58%) (Figure⇓). Five trials trended in favor of PUFA and two trials in favor of placebo.
Conclusion: Dietary supplementation with PUFA leads to reduced risk of sudden cardiac death and ventricular arrhythmias. A greater utilization of PUFA in the diet merits further investigation.