Abstract 4109: SNPs in the LRP8/ApoER2 Gene on Chromosome 1p34–36 Are Implicated in Conferring High Risks for Myocardial Infarction (MI) in Multiple Racial Populations
LRP8 is a gene located on chromosome 1p34–36, the significantly linked genetic locus for susceptibility to MI identified by our genome-wide linkage scan of 428 nuclear families in the U.S previously. In last year, we established that LRP8 is a susceptibility gene for MI in American Caucasians using a population-based case-control association study consisting of 381 cases selected from the well-characterized CAD/MI probands from each family with DNA available and the 315 controls showing no detectable stenosis by coronary angiography. This study aims to reveal any genetic implication of LRP8 in other population(s). Large-scale samples from Italians consisting of 416 MI cases and 305 normal controls are thus recruited and genotyped for the same five SNPs using the 5′ nuclease allelic discrimination assay with an ABI Prism 7900HT Sequence Detection System. The genotyping data yielding positive associations were verified by direct DNA sequence analysis. The allelic associations of SNPs with MI were evaluated using Pearson’s Chi-square test. These results in the below table⇓ show that the genetic variants in LRP8 are also significantly associated with MI in the Italian population, which implicates that LRP8 may confer high risks for MI in multiple racial populations.