Abstract 4104: The Joint Impact of Visceral Adipose Tissue and Body Mass Index on Metabolic Risk Factors for Cardiovascular Disease: the Framingham Heart Study
Background Abdominal adipose tissue compartments confer differential metabolic risk. Visceral adipose tissue (VAT) is associated with an adverse metabolic risk profile even after accounting for standard anthropometric indices. We now seek to examine the impact of VAT on metabolic CVD risk factors among individuals across body mass index (BMI) categories.
Methods Participants from the Framingham Heart Study Offspring and Third Generation cohorts (n=3001, 48% women, mean age 50 years), free of CVD, underwent computed tomography assessment of VAT between years 2002–2005. Hypertension (HTN), impaired fasting glucose (IFG), diabetes (DM), and metabolic syndrome (metS), determined using standard criteria, were examined in relation to sex-specific VAT quartiles among normal weight (BMI<25 kg/m2), overweight (BMI 25–29.9), and obese (BMI 30+) individuals after adjustment for age, sex, and BMI; p-values for linear trend across VAT quartiles were computed.
Results Thirty-three percent of the sample were normal weight, 41% overweight, and 26% obese. Among overweight and obese individuals, age-sex-and -BMI adjusted risk factor prevalences increased linearly and significantly across increasing VAT quartiles (Figure⇓). Among normal weight individuals, significant increasing trends were seen only for IFG (p-value for trend=0.007) and HTN (p-value for trend=0.008). Similar relations were noted in separate analyses for women and men.
Conclusions VAT provides significant incremental information regarding metabolic CVD risk factors. Quantitative measurements of VAT may provide a more complete understanding of metabolic risk associated with variation in fat distribution.