Abstract 4100: Coffee Consumption does not Increase Cardiovascular Risk
Background. Although it has been extensively studied, the relation between coffee consumption and cardiovascular disease is still debated. In view of these discrepancies we evaluated the long-term effect of coffee consumption on cardiovascular disease.
Methods We used prospectively ascertained information among 11,231 Italian patients, 9,584 males and 1,647 females, with recent (≤3 months) MI enrolled in GISSI-Prevenzione Trial. Number of cups of coffee/day (0, 1, 2– 4, and >4) was assessed at baseline and updated at 0.5 and 1.5 years. The outcome measure was total cardiovascular events (CVE) including cardiovascular death, non-fatal MI, and non-fatal-stroke assessed at 0.5, 1, 1.5, 2.5, and 3.5 years. Risk was evaluated using Cox proportional hazards with time-varying covariates.
Results During 38,113 person-years, occurred 1,167 CVE. After adjustment for other potential confounding factors, we found no significant association between long-term coffee consumption and risk of CVE. This null association was independent of sex (P for interaction = 0.90), diabetes mellitus (P for interaction =0.07) obesity (P for interaction = 0.88) and smoking status (P for interaction =0.84).
Conclusions We did not find evidence of a detrimental effect of long term coffee intake on risk of CVE in post MI patients.