Abstract 4073: Relationship Between Physical Activity and C-Reactive Protein Level in the Multi-Ethnic Study of Atherosclerosis
Objective: To examine the association between physical activity (PA) and high sensitivity c-reactive protein (hs-CRP) level in a multi-ethnic cohort of middle aged Caucasian, Chinese, African American (AA) and Hispanic participants.
Background: Studies have identified an inverse relationship between PA and hs-CRP, but the results were inconsistent, partly due to differences in PA measurement. Additionally, the effect of race on the association has not been determined.
Methods: We analyzed baseline data from 6291 participants aged 45– 84 enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA). Combined vigorous plus moderate PA (Vig+Mod PA) was measured by self-reported leisure, conditioning, occupational and household activities. Vig+Mod PA was expressed as MET-minutes per week and plasma hs-CRP was measured using the BNII nephelometer and expressed in mg/L. Analysis of covariance was used to assess the association between hs-CRP and Vig+Mod PA, by gender and racial/ethnic groups. To be conservative, the Bonferroni adjustment for multiple comparisons was used (p < 0.05 / 8 = 0.00625).
Results: hs-CRP was highest in AA and lowest in Chinese participants. After adjusting for age, BMI, smoking status, blood pressure, diabetes, LDL, HDL, use of BP medication, aspirin, statins, and hormone replacement therapy (in women), hs-CRP decreased across tertiles of Vig+Mod PA level in Hispanic men (p = 0.004) (Table 1⇓). There was a downward trend in hs-CRP across tertiles of Vig+Mod PA in AA and Caucasian men, but the trend was not significant using the adjusted significance level of 0.00625. A clear trend was not observed in any female racial/ethnic groups.
Conclusions: These findings suggest that the inverse association between Vig+Mod PA and hs-CRP level may be modified by race and gender in the MESA cohort. Further studies are needed to confirm these findings and to examine the possible mechanisms for the race and gender differences in the association between PA and hs-CRP.