Abstract 4071: Association of Plasma Total IGF-I, IGFBP-1 and IGFBP-3 Levels with Incident Coronary Heart Disease and Ischemic Stroke
Background The growth hormone/insulin-like growth factor (GH/IGF) axis declines with aging. Whether these age-related changes have an impact on vascular disease risk is unclear. We assessed the association between levels of total IGF-I and IGF binding proteins (IGFBP-1, IGFBP-3) and risk of incident myocardial infarction (MI), fatal coronary heart disease (CHD), and ischemic stroke in a case-cohort study among adults >65 years old.
Methods and Results From among participants in the Cardiovascular Health Study (CHS), we identified 364 fatal or non-fatal MIs, 170 fatal CHD events, 370 ischemic strokes, and 1,122 randomly-selected comparison subjects. Mean follow-up time was 9.3 years. Hazard ratios (HRs) [95% confidence intervals] associated with baseline levels of total IGF-I and IGFBPs were estimated using Cox proportional hazards models that adjusted for age, gender, hypertension, systolic blood pressure, smoking, creatinine, high density lipoprotein cholesterol and race/ethnicity. Neither IGF-I nor IGFBP-1 levels predicted risk of incident coronary events (MI plus CHD) or stroke. IGFBP-3 had a borderline inverse association with risk of coronary events (adjusted HR per standard deviation = 0.88 [0.78–1.01], p=0.06), but was not associated with stroke.
Conclusions Circulating levels of total IGF-I or IGFBP-1 were not associated with risk of total coronary events or ischemic stroke among older adults, while low IGFBP-3 level tended to be associated with increased risk of incident coronary events.