Abstract 4068: Association of Monocyte Chemoattractant Protein-1 and Soluble Intercellular Adhesion Molecule-1 with Coronary Artery Calcification in the National Heart, Lung, and Blood Institute Family Heart Study Follow-up Examination
It has been well recognized that the development of atherosclerosis involves inflammation. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in recruitment of monocytes to sites of atherosclerotic lesions, and intercellular adhesion molecule-1 (ICAM-1) participates in inducing firm adhesion of leukocytes to vascular surfaces. In prospective studies, plasma levels of both MCP-1 and the soluble form of ICAM-1 (sICAM-1) have been shown to predict incidence of coronary heart disease (CHD). However, the utility of sICAM-1 and MCP-1 as biomarkers for subclinical atherosclerosis is less clear. In the second exam of the NHLBI Family Heart Study, we evaluated whether sICAM-1 and MCP-1 are associated with coronary artery calcium (CAC), a measure of the burden of coronary atherosclerosis. CAC was measured using the Agatston score with multidetector computed tomography. Levels of sICAM-1 and MCP-1 were measured in citrated plasma by ELISA assays. Information on CAC, sICAM-1 and MCP-1 was obtained in 2715 subjects (17% African Americans, 60% females, mean age 55 years) without a history of CHD or revascularization procedures. The association of sICAM-1 and MCP-1 with CAC was investigated by generalized estimating equations which accounted for familial relatedness. There was a significant association between sICAM-1, the presence of CAC (CAC>0), and the amount of CAC in those with detectable CAC, even after controlling for demographic variables and traditional CHD risk factors. MCP-1 was significantly associated with the presence and amount of CAC after adjusting for demographic variables, but not after additionally adjusting for traditional risk factors. Addition of CRP to the multivariable adjustment did not affect the above results. In conclusion, our study suggests that sICAM-1 is a biomarker of coronary atherosclerotic burden in addition to the information provided by traditional risk factors and CRP.