Abstract 4065: Chemokines and Risk of Myocardial Infarction: Results from the MONICA/KORA Augsburg Study, 1984–2002
Background: The chemokines monocyte chemoattractant protein-1 (MCP-1/CCL2), interleukin-8 (IL-8/CXCL8) and interferon-gamma-inducible protein-10 (IP-10/CXCL10) are expressed and released by adipocytes. They have been reported to be involved in the development of atherosclerosis and type 2 diabetes. Therefore, we investigated prospectively whether increased levels of these chemokines at baseline are associated with an increased risk of incident CHD events.
Methods: A case-cohort study was conducted in middle-aged men and women based on data from the MONICA/KORA Augsburg studies collected between 1984 and 2002. Concentrations of various chemokines were measured using Luminex technology in stored samples of 381 case subjects with incident CHD events and 1977 non-case subjects. The mean follow-up time was 11.0 years.
Results: Baseline concentrations were significantly higher in cases compared to non-cases (P <<26> 0.001 for all chemokines). Elevated concentration of MCP-1 and IL-8 remained associated with risk of myocardial infarction after adjustment for age, sex and survey with hazard ratios (95% confidence intervals, CI) comparing extreme tertiles of 1.39 (1.05–1.84) for MCP-1 and 1.48 (1.10–1.99) for IL-8. However, adjustment for further cardiovascular risk factors and inflammatory markers such as CRP and IL-6 attenuated the observed associations: HR (95% CI), comparing extreme tertiles were 1.30 (0.96–1.75) for MCP-1 and 1.32 (0.95–1.83) for IL-8. For the association of MCP-1, IL-8 and IP-10 with CHD risk, age was the strongest single confounder for all three chemokines.
Conclusions: We therefore conclude that elevated systemic levels of the chemokines MCP-1, IL-8 and IP-10 precede CHD, but do not represent independent risk factors. Thus, the associations are less pronounced than previously shown for type 2 diabetes risk.