Abstract 4059: Serum Ferritin Interacts with Menopausal Status in its Association with Blood Pressure in Adult Women: National Health and Nutrition Examination Survey (NHANES), 2001–2002
Objective: To assess the relationship between serum ferritin and blood pressure among a nationally representative sample of U.S. women, and to determine whether menopausal status modifies the ferritin-blood pressure association in this population.
Methods: NHANES 2001–2002 is a national non-institutionalized representative survey of the US population. Premenopausal (N=1261) and postmenopausal women (N=1076), aged 20 years and older, free of cardiovascular diseases, anemia, hepatitis, and hemachromatosis were included in this study. Menopausal status was defined as having had no menstrual periods in the past 12 months due to the natural aging process or surgical removal of ovary or uterus. Systolic and diastolic blood pressure (SBP, DBP) and pulse pressure (PP) were dependent variables in multivariate regression models that were adjusted for age, race/ethnicity, current smoking and drinking status, body mass index and hypercholesterol-emia. An interaction analysis was performed to assess whether the association between ferritin quartiles and blood pressure differed by menopausal status.
Results: Postmenopausal women had higher levels of serum ferritin than premenopausal women (104.6±3.1 vs 50.0 ±3.1 ng/ml, p<0.0001), after controlling for the covariates. In multivariate analysis, higher ferritin was related to an elevated SBP and PP in postmenopausal women while these associations were not significant among premenopausal women (interaction analysis, p=0.05 for SBP and p=0.04 for PP). The adjusted least-square means and their standard errors of SBP and PP by ferritin quartiles are shown in the table⇓ below. No significant association between ferritin and DBP was found for either group.
Conclusion: Serum ferritin interacts with menopausal status in its association with blood pressure among women. Relatively higher iron storage may be part of the underlying mechanism for loss of cardiovascular protection among postmenopausal women.